| Autor: |
Thanh Luan, Nguyen Ngoc, Okada, Takuya, Yokoyama, Takeshi, Suzuki, Mie, Nabeshima, Yuko, Mizuguchi, Mineyuki, Toyooka, Naoki |
| Zdroj: |
Journal of Natural Products; 20240101, Issue: Preprints |
| Abstrakt: |
We have achieved the divergent total synthesis of nine isoflavone natural products 1–9starting from commercially available 2,4,6-trihydroxyacetophenone as a starting material. The isoflavone skeleton of 1–9was constructed by the Suzuki–Miyaura coupling reaction as the key reaction. Investigation of the potential of 1–9as therapeutic agents for transthyretin (TTR) amyloidosis revealed that millexatin F (3) showed the best efficacy in ex vivocompetitive binding experiments and thioflavin-T fluorescence studies. Therefore, millexatin F (3) is promising as a seed compound for a novel TTR amyloidosis therapeutic agent. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
|
