| Autor: |
Rabb, H., Mendiola, C.C., Saba, S.R., Dietz, J.R., Smith, C.W., Bonventre, J.V., Ramirez, G. |
| Zdroj: |
Biochemical and Biophysical Research Communications; June 1995, Vol. 211 Issue: 1 p67-73, 7p |
| Abstrakt: |
ICAM-1 has been implicated in the pathophysiology of ischemic-reperfusion injury in a number of organs, but its role in mediating severe ischemic-reperfusion injury in the kidney has not been extensively studied. Uninephrectomized Sprague Dawley rats were pretreated with either control monoclonal antibody (mAb) or mAb to ICAM-1 and subjected to 60 min of renal artery occlusion. The serum creatinine, complete blood count and kidney histo-pathological damage scores (PDS) (Scale:0-4) were assessed prior to and 24 hours after ischemia. Mean serum creatinine (mg/dl) 24 hours after ischemia was significantly decreased in the anti-ICAM-1 group (1.38 ± 0.23, p<0.001) compared to control (2.87 ± 0.34). PDS was also reduced in anti-ICAM-1 (2.55 ± 0.20, p<0.05) group compared to control (3.35 ± 0.30). These data demonstrate that blocking ICAM-1 significantly mitigates severe ischemic acute renal failure, findings which may lead to improved therapy for this condition. |
| Databáze: |
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