| Autor: |
Sobhy, Mohamed, Eletriby, Adel, Ragy, Hany, Kandil, Hossam, Saleh, Mohamed Ayman, Farag, Nabil, Guindy, Ramez, Bendary, Ahmed, Nayel, Ahmed Mohamed Elmahmoudy, Shawky, Ahmed, Khairy, Ayman, Mortada, Ayman, Zarif, Bassem, Badran, Haitham, Khorshid, Hazem, Mahmoud, Kareem, Said, Karim, Leon, Khaled, Abdelsabour, Mahmoud, Tawfik, Mazen, Abdelmegid, Mohamed Aboel-Kassem F., Koriem, Mohamed, Loutfi, Mohamed, Wadie, Moheb, Elnoamany, Mohamed, Sadaka, Mohamed, Seleem, Mohamed, Zahran, Mohamed, Amin, Osama A., Elkaffas, Sameh, Ayad, Sherif, Kilany, Wael El, Ammar, Walid, Elawady, Waleed, Elhammady, Walid, Abdelhady, Yasser |
| Zdroj: |
Cardiology and Therapy; 20240101, Issue: Preprints p1-30, 30p |
| Abstrakt: |
Overstimulation of the renin–angiotensin–aldosterone system—a key regulator of blood pressure, and fluid and electrolyte balance—is known to cause an increase in blood pressure (also known as “hypertension”) and other diseases of the heart and blood vessels (the cardiovascular system). As such, treatments to block (or inhibit) this overstimulation are an essential part of medical strategies designed for the prevention of cardiovascular disease, especially in patients with hypertension (in whom the risk of death due to cardiovascular causes is high). Angiotensin-converting enzyme inhibitors and angiotensin receptor blockers are two types of medication that block overstimulation of the renin–angiotensin–aldosterone system, but they work in different ways. Angiotensin-converting enzyme inhibitors are superior to angiotensin receptor blockers after heart attacks (acute myocardial infarction), in patients with heart failure, for the prevention of stroke in individuals who have already had a stroke, and in patients with diabetes. Both types of medication have beneficial effects on the kidneys and associated outcomes, but only angiotensin-converting enzyme inhibitors have been shown to significantly reduce death due to cardiovascular causes, as well as death due to any cause. Overall, the protective effects of angiotensin-converting enzyme inhibitors on the heart are substantially greater than those of angiotensin receptor blockers, meaning that treatment with an angiotensin-converting enzyme inhibitor is preferred in all patients, except those who cannot tolerate the side effects of this drug class. |
| Databáze: |
Supplemental Index |
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