| Autor: |
Orfanoudaki, Maria, Dalilian, Masoumeh, Du, Lin, Chau, Cindy H., Figg, William D., O’Keefe, Barry R., Grkovic, Tanja |
| Zdroj: |
Journal of Natural Products; 20240101, Issue: Preprints |
| Abstrakt: |
Chemical profiles of Latrunculia kaakaarikiand Latrunculia breviswere investigated, resulting in the isolation of five new discorhabdin D derivatives 1and 3–6. Their planar structures were solved by combination of NMR and HR-MS, while J-based configurational analysis, computational techniques, and semisynthetic methods were used for the establishment of their absolute configurations. New natural products were tested for their growth inhibitory activity against the NCI-60 human tumor cell line panel, and two compounds 5and 6showed low micromolar potency. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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