| Autor: |
Kamińska, Kinga, Tchurzyk, Marcelina, Fraczek, Olga, Szlaga, Agata, Sambak, Patryk, Tott, Szymon, Małek, Kamilla, Knapczyk-Stwora, Katarzyna, Błasiak, Anna, Rak, Agnieszka, Grzesiak, Małgorzata |
| Zdroj: |
Annals of Animal Science; October 2024, Vol. 24 Issue: 4 p1197-1209, 13p |
| Abstrakt: |
Polycystic ovary syndrome (PCOS) is a common endocrinopathy in women of reproductive age leading to infertility. Besides reproductive and hormonal disturbances, PCOS is often characterized by vitamin D3(VD) deficiency. This study aimed to determine the effect of VD on uterine histoarchitecture, the biochemical composition of gland secretions, and the insulin signal transduction pathway using a PCOS rat model. The experiment was conducted on four animal groups (n=8/group): control (C), VD supplemented (VD; 500 IU/day), letrozole-treated (PCOS; 1 mg/kg body weight), and VD-treated PCOS (PCOS+VD) group. Herein, VD supplementation did not improve histomorphometric parameters in the PCOS uterus, whereas clearly influenced sugar composition in uterine gland secretions, restoring their content to that observed in the C group. Furthermore, we found that VD can reduce peripheral and local uterine insulin resistance developed in the PCOS rats viaactivation of the phosphoinositide 3-kinase (PI3K)/protein kinase B (Akt) signaling pathway and subsequent glucose metabolism in the uterus. To sum up, the present results suggest a possible beneficial role of VD supplementation for the maintenance of uterus functions in PCOS rats. |
| Databáze: |
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