| Autor: |
Caneo, Luiz Fernando, Turquetto, Aida Luiza Ribeiro, Rodrigues Gonçalves, Fábio Augusto, Trindade, Evelinda Marramon, Buchholz, Holger, Garros, Daniel, Miana, Leonardo Augusto, Massoti, Maria Raquel Brigoni, Tanamati, Carla, Penha, Juliano Gomes, Jatene, Marcelo Biscegli, Jatene, Fabio Biscegli |
| Zdroj: |
World Journal for Pediatric and Congenital Heart Surgery; 20240101, Issue: Preprints |
| Abstrakt: |
Background:In newly emerging economy countries, the shortage of pediatric donor hearts and poor healthcare infrastructure poses a significant challenge. Although mechanical circulatory support (MCS) has been proven effective in enhancing heart transplant waiting list outcomes, economic barriers hinder its widespread adoption. Methods:A single-center retrospective study reviewed children under 10 kg on the heart transplant (HTx) list from 2012 to 2023. Elective or priority status was assigned based on their clinical condition at the time of transplant. In cases of clinical decompensation, centrifugal pump and extracorporeal membrane oxygenation, transitioned to the Berlin Heart EXCOR (BHE) pediatric ventricular assist device (VAD) was employed. Pre- and post-HTx outcomes were analyzed with descriptive statistics, Cox regression, and competing survival risks. Results:Out of 81 infants on the HTx list, 61.7% (50/81) were in critical condition. The median wait time was 224 days, and 34% (28/81) died while waiting. Out of 37 transplanted patients, 6 (16%) had graft dysfunction, and 10 (27%) had acute renal injury. Survival to discharge was 84% (31/37). Patients who received the BHE exhibited higher chances of receiving a transplant (hazard ratio: 2.3; 95% confidence interval: 1.2-4.6; P= .01). Priority status or MCS use did not significantly impact mortality post-transplant. Conclusion:Advanced MCS technologies can potentially reduce the mortality risk on the pediatric HTx waitlist. The findings highlight the significant waiting time for HTx and the critical role of the BHE in improving outcomes in children, particularly those under 10 kg. The results advocate for the adoption of ventricular assist devices as a viable interim solution to bridge critically ill children to HTx, ultimately enhancing their chances of survival despite limited donor heart availability. |
| Databáze: |
Supplemental Index |
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