| Autor: |
Yang, Ann Fan, Sherman, Adrienne, Nazarian, Elizabeth, Haas, Wolfgang, Mehr, Jason, Pedrani, Michele, Kirn, Thomas, Brant, Steven, Boruchoff, Susan E., Kaye, Keith S., Mills, John P. |
| Zdroj: |
Infection Control & Hospital Epidemiology; August 2024, Vol. 45 Issue: 8 p973-978, 6p |
| Abstrakt: |
AbstractObjective:To investigate the source and transmission dynamics of an endoscope-associated New Delhi metallo-β-lactamase-producing Klebsiella pneumonia(NDM-KP) outbreak.Design:Epidemiological and genomic investigation.Setting:Academic acute care hospital in New Jersey.Patients:Five patients with active NDM-KP infection identified on clinical isolates, and four NDM-KP colonized patients identified via rectal swab screening.Results:Over a twelve-month period, nine patients were identified with NDM-KP infection or colonization. Whole-genome sequencing (WGS) revealed that all of the identified cases were related by 25 mutational events or less. Seven of the cases were linked to gastrointestinal endoscopic procedures (four clinical cases and three positive screens among patients exposed to endoscopes suspected of transmission). Two cases demonstrated delayed transmission that occurred five months after the initial outbreak, likely through shared usage of a non-therapeutic gastroscope without an elevator channel.Conclusions:Although all endoscope cultures in our investigation were negative, the epidemiological link to gastrointestinal endoscopes, the high degree of relatedness via WGS, and the identification of asymptomatic NDM-KP colonization among patients exposed to shared endoscopes make the endoscopic mode of transmission most likely. This investigation highlights the probable transmission of NDM-KP via a gastroscope without an elevator channel, observed several months after an initial outbreak. We hypothesize that persistent mechanical defects may have contributed to the delayed device-related transmission of NDM-KP. |
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