The Longitudinal Antibiotic Susceptibility Pattern Among Gram-negative Bacteria Causing Neonatal Sepsis—From an Eastern Indian Tertiary Care Facility

Autor: Pradhan, Deepti Damayanty, Sahoo, Swaranjika, Hasa, Vetsa Snigdha, Pugalia, Rishabh, Panda, Santosh Kumar
Zdroj: Journal of Neonatology; 20240101, Issue: Preprints
Abstrakt: The trend of antimicrobial susceptibility of isolated gram-negative bacteria (GNB) causing neonatal sepsis over a span of six years in a tertiary care neonatal unit in eastern India is reported. The GNB microorganism profile had not changed, but the sensitivity to commonly prescribed higher antimicrobial piperacillin and tazobactam (PIP/TZ) (27.7%-11.6%, p= .013), fluoroquinolone (64%-23.3%, p= .001) had significantly declined. The prevalence of multi-drug resistance (MDR) GNB had increased from 40% to 60%. The sensitivity pattern of GNB for various combinations of empirical antimicrobials is also presented.
Databáze: Supplemental Index