A herbal pair of Scutellaria barbataD. Don and Scleromitrion diffusum(Willd.) R.J. Wang induced ferroptosis in ovarian cancer A2780 cells via inducing heme catabolism and ferritinophagy

Autor: Wang, Zhen, Liu, Min, Li, Guang-xing, Zhang, Liu, Ding, Kai-yue, Li, Si-qi, Gao, Bing-qing, Chen, Peng, Choe, Hyok-Chol, Xia, Lun-yue, Yang, Yu-tong, Liu, Yi, Sui, Xue, Ma, Jun-nan, Zhang, Lin
Zdroj: Journal of Integrative Medicine (JIM); November 2024, Vol. 22 Issue: 6 p665-682, 18p
Abstrakt: Despite the combination of Scutellaria barbataD. Don and Scleromitrion diffusum(Willd.) R.J. Wang (SB-SD) being a recognized Chinese medicinal herbal pair that is commonly used in the treatment of ovarian cancer, there is a poor understanding of their pharmacological mechanisms. This study examines the antitumor properties and potential mechanisms of SB-SD on human ovarian cancer A2780 cells through a multi-omics approach, establishing a pharmacological basis for clinical utilization.
Databáze: Supplemental Index