| Abstrakt: |
Polypropylene imine (PPI) dendrimer has antimicrobial efficiency, bioactivity, and enhanced biocompatibility. Scandium dioxide (Sc2O3) has cell viability, cell growth, cell proliferation, and biostability. Sc2O3-PPI dendrimer nanocomposite-coated Ti substrate was studied for its bioactivity by immersing in Kokubo’s simulated body fluid for 21 days at 36.5oC (pH: 7.4). The physio-chemical and electrochemical characterization revealed a high level of crystallinity and exhibited superior adhesion and biostability to the Ti substrate. Vickers microhardness test under various loads (50 gm) confirmed the mechanical stability of the coatings. SEM-EDS studies demonstrated that the formation of a homogenous apatite layer on the surface of the coatings was produced by the interaction of the Sc2O3-PPI dendrimer nanocomposite coating and simulated body fluid. In vitro antibacterial and in vitro cytotoxicity tests were used to evaluate the antibacterial properties and toxic effects of the Sc2O3-PPI dendrimer nanocomposite coatings. The coating excellently inhibited bacterial activity, and the highest zone of inhibition was obtained for S. aureus(gram-positive bacteria) and P. aeruginosa(gram-negative bacteria). Moreover, employing the theoretical studies of a small model system, stability of Sc2O3-PPI dendrimer composite is also explained by the existence of a hydrogen bond as well as Sc and O interaction. Preferential doping of PPI dendrimer into Sc2O3proved high bioactivity, effective antibacterial properties, great mechanical stability of the coating, and no evidence of cytotoxic effect, suggesting that the Sc2O3-PPI dendrimer nanocomposite coating is expected to be a promising bioactive long-term orthopedic implant. |
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