| Autor: |
Woollard, A., Basi, G., Nurse, P. |
| Zdroj: |
The EMBO Journal; September 1996, Vol. 15 Issue: 17 p4603-4612, 10p |
| Abstrakt: |
We have cloned a novel fission yeast gene, spd1, which causes G1 arrest when overexpressed. Deleting the gene results in cells being accelerated through G1 into S phase in certain circumstances when the G1–>S phase control is compromised. We have found that the encoded 14 kDa protein is cell cycle regulated, declining in level during S phase, and that p14spd1 physically associates with p34cdc2 in vivo when overexpressed, suggesting that p14spd1 may regulate S phase progression via an interaction with p34cdc2. We conclude that p14spd1 is a negative regulator of S phase, and that it may be part of the control ensuring an orderly onset of S phase or part of a G1–>S phase checkpoint control. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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