| Autor: |
Ladner, M. B., Martin, G. A., Noble, J. A., Nikoloff, D. M., Tal, R., Kawasaki, E. S., White, T. J. |
| Zdroj: |
The EMBO Journal; September 1987, Vol. 6 Issue: 9 p2693-2698, 6p |
| Abstrakt: |
Bone marrow progenitor cells differentiate into mononuclear phagocytes in the presence of colony stimulating factor‐1 (CSF‐1). Characterization of the human CSF‐1 gene shows that it contains 10 exons and 9 introns, which span 20 kb. Analysis of multiple CSF‐1 transcripts demonstrates that alternate use of exon 6 splice acceptor sites and 3′ noncoding sequence exons occurs. These alternatively spliced transcripts can encode either a 224 or a 522 amino acid CSF‐1. Implications of differential splicing for the production and function of CSF‐1 are discussed. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
|
