| Autor: |
Hinkle, Jared T., Wildermuth, Erin, Tong, Xiao J., Ross, Christopher A., Bang, Jee |
| Zdroj: |
Journal of Huntington's Disease; September 2024, Vol. 13 Issue: 3 p315-320, 6p |
| Abstrakt: |
Background: Anosognosia, or unawareness of symptoms, is common in Huntington’s disease (HD), but the neuroanatomical basis of this is unknown.Objective: To identify neuroanatomical correlates of HD anosognosia using structural MRI data.Methods: We leveraged a pre-processed dataset of 570 HD participants across the well-characterized PREDICT-HD and TRACK-HD cohort studies. Anosognosia index was operationalized as the score discrepancies between HD participants and their caregivers on the Frontal Systems Behavior Scale (FrSBe).Results: Univariate correlation analyses identified volumes of globus pallidus, putamen, caudate, basal forebrain, substantia nigra, angular gyrus, and cingulate cortex as significant correlates of anosognosia after correction for multiple comparisons. A multivariable model constructed with stepwise regression that included volumetric data showed globus pallidus volume alone explained more variance in anosognosia severity than motor impairment or CAP score alone.Conclusions: Anosognosia appears to be related to degeneration affecting both cortical and subcortical areas. Globus pallidus neurodegeneration in particular appears to be a key process of importance. |
| Databáze: |
Supplemental Index |
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