| Autor: |
Panajotopoulos, Nicolas, Ianhez, Luiz E., Neumann, Jorge, Rosales, Claudia, Sabbaga, Emil, Kaill, Jorge |
| Zdroj: |
Clinical Transplantation; Part 16/June 1992, Vol. 6 Issue: 3 p196-198, 3p |
| Abstrakt: |
The role of antibodies specific to donor B‐cell antigens in renal transplantation remains to be firmly established. We have used, in a sensitized patient awaiting his second transplant, reduction with dithiothreitol (DTT), platelet absortion and panel reactivity analysis to identify imunoglobulin class and specificity of the antibody causing positive B‐cell crossmatch. The results show that the antibody was an IgG anti‐HLA DR5. The transplant was performed using the recipient's mother, specifically mismatched for DR5, as donor. The graft has excellent function 18 months after transplantation. The experience with this patient raises questions about the clinical significance of anti‐DR antibodies, and of anti‐B cells antibodies in general, in kidney transplantation. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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