| Autor: |
Schütze, Sandra, Döpke, Anika, Kellert, Benedikt, Seele, Jana, Ballüer, Melissa, Bunkowski, Stephanie, Kreutzfeldt, Mario, Brück, Wolfgang, Nau, Roland |
| Zdroj: |
Journal of Alzheimer's Disease Reports; October 2022, Vol. 6 Issue: 1 p101-114, 14p |
| Abstrakt: |
Background: In patients with Alzheimer’s disease (AD), bacterial infections are often associated with a cognitive decline. Animal models of genuine acute infections with viable bacteria which induce deterioration of neurodegenerative diseases are missing.Objective: We assessed the effect of an intracerebral infection with E. coliin a mouse model of AD.Methods: 13-month-old Tg2576 +/- mice and transgene negative littermates (Tg2576 -/-) received an intracerebral injection with E. coliK1 or saline followed by treatment with ceftriaxone starting 41 h post infection (p.i.) for 5 days. For 4 weeks, mice were monitored for clinical status, weight, motor functions, and neuropsychological status using the Morris water maze. ELISAs, stainings, and immunohistochemistry in brains were performed at the end of the experiment.Results: Mortality of the infection was approximately 20%. After 4 weeks, spatial learning of infected Tg2576 +/- mice was compromised compared to non-infected Tg2576 +/- mice (p?
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| Databáze: |
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