Anti-Radiofibrosis Effect of Dicliptera chinensisPolysaccharide on Rat Dermal Fibroblasts Via The TGF-β1/Smads/CTGF Signaling Pathway

Autor: Huang, Yude, Zhao, Lixiang, Zhao, Yanfei, Fan, Yiyang, Gao, Linjing, Lu, Haoyu, Wang, Xian, Mo, Dongqin, Wang, Daiyou
Zdroj: International Dental Journal; 20240101, Issue: Preprints
Abstrakt: Radiotherapy is an effective treatment for head and neck cancer; however, irradiated normal tissues are inevitably damaged, resulting in skin radioactive fibrosis. Dicliptera chinensispolysaccharide (DCP), the primary active compound extracted from the natural medicinal Dicliptera chinensis, exhibits antioxidant, anti-inflammatory, and anti-radiation properties. In this study, we investigated the protective effects of DCP against radioactive fibrosis in rat dermal fibroblasts (RDF) and explored the underlying mechanisms involved.
Databáze: Supplemental Index