| Autor: |
Deep, Deeksha, Gudjonson, Herman, Brown, Chrysothemis C., Rose, Samuel A., Sharma, Roshan, Paucar Iza, Yoselin A., Hong, Seunghee, Hemmers, Saskia, Schizas, Michail, Wang, Zhong-Min, Chen, Yuezhou, Wesemann, Duane R., Pascual, Virginia, Pe’er, Dana, Rudensky, Alexander Y. |
| Zdroj: |
The Journal of Experimental Medicine; October 2024, Vol. 221 Issue: 10 pe20231193-e20231193, 1p |
| Abstrakt: |
Upon antigenic stimulation, naïve CD4+ T cells can give rise to phenotypically distinct effector T helper cells and long-lived memory T cells. We computationally reconstructed the in vivo trajectory of CD4+ T cell differentiation during a type I inflammatory immune response and identified two distinct differentiation paths for effector and precursor central memory T cells arising directly from naïve CD4+ T cells. Unexpectedly, our studies revealed heterogeneity among naïve CD4+ T cells, which are typically considered homogeneous save for their diverse T cell receptor usage. Specifically, a previously unappreciated population of naïve CD4+ T cells sensing environmental type I IFN exhibited distinct activation thresholds, suggesting that naïve CD4+ T cell differentiation potential may be influenced by environmental cues. This population was expanded in human viral infection and type I IFN response-lined autoimmunity. Understanding the relevance of naïve T cell heterogeneity to beneficial and maladaptive T cell responses may have therapeutic implications for adoptive T cell therapies in cancer immunotherapy and vaccination. |
| Databáze: |
Supplemental Index |
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