Drug-induced hyponatraemia and possible related signals: Analysis of 659 cases reported to the Spanish Pharmacovigilance System and disproportionality analysis

Autor: Estévez Asensio, Lucía, García, Montserrat, Verde Rello, Zoraida, Velasco-González, Verónica, Fernández-Araque, Ana M., Sainz-Gil, María
Zdroj: Medicina Clínica (ScienceDirect); December 2024, Vol. 163 Issue: 12 p600-608, 9p
Abstrakt: Hyponatraemia has negative effects on cognitive function and gait stability and is a risk factor for osteoporosis, falls, fractures and hospital mortality. Acute hyponatraemia can lead to neurological dysfunction due to cerebral oedema. Its rapid correction can also be fatal, leading to osmotic demyelination syndrome. For some antiepileptics, thiazides, benzodiazepines or antidepressants this reaction is widely described. Knowing which drugs are most likely to cause hyponatraemia will allow early detection and prevention of its complications, as well as individualising the prescription of these drugs according to the patient's characteristics.
Databáze: Supplemental Index