Development of Ion Channel Analysor Employing Pores of Subunit C of ATP Synthase

Autor:	McGeoch, J E M
Zdroj:	Microscopy and Microanalysis; August 2000, Vol. 6 Issue: 1, Number 1 Supplement 2 p978-979, 2p
Abstrakt:	Many pathological states are related to aberrant functioning of ion channels. Cures for these conditions involve the design of chemicals that will interact with the ion channels or a channel regulator to return their function to the normal level. A notable example of a pathological state associated with ion channel malfunction is the abnormal conductance of inward rectifying potassium channels associated with irregular heart beat. The development of drugs targeting ion channels requires efficient screening of thousands of potential channel ligands. Classically the function of ion channels are assayed by patch clamping which is a fairly elaborate technique and not efficient from the point of screening thousands of ligands. Here is described the development of a compact sensor device where an ion channel is made to function in a lipid bilayer in 50nm holes in silicon or polymer hardware.
Databáze:	Supplemental Index
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