The effects of the MTHFR677C>T (rs1801133) genetic variant on susceptibility and disability worsening in multiple sclerosis patients are mediated by homocysteine

Autor: Ribeiro, Claudia Mara, Oliveira, Sayonara Rangel, Flauzino, Tamires, Alfieri, Daniela Frizon, Simão, Andrea Name Colado, Lozovoy, Marcell Alysson Batisti, Maes, Michael, Reiche, Edna Maria Vissoci
Zdroj: Multiple Sclerosis and Related Disorders; November 2024, Vol. 91 Issue: 1
Abstrakt: •The MTHFR677C>T variant was not associated with multiple sclerosis and disability.•The TT genotype has an indirect effect on susceptibility and disability via homocysteine.•Age and inflammatory biomarkers are positively associated with disability.•Disability progression variance was predicted by inflammation biomarkers (positively).•Disability progression variance was predicted by 25-hydroxyvitamin d (negatively).
Databáze: Supplemental Index
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