| Autor: |
Pimentel, Guilherme A., Santos-Navarro, Fernando N., Dewasme, Laurent, Wouwer, Alain Vande |
| Zdroj: |
IFAC-PapersOnLine; January 2024, Vol. 58 Issue: 14 p422-427, 6p |
| Abstrakt: |
This paper presents a systematic data-driven methodology to infer macroscopic reaction schemes and their associated kinetic laws from the measurements of concentration trajectories. The procedure uses sparse identification incorporated with a generic kinetic structure combining activation and inhibition factors. Only measurements of the extracellular species, i.e., biomass, substrates, and products of interest, are required, and measurement noise can be tackled using specific regularization techniques. The methodology is illustrated with a case study of a synthetic dataset from the production of therapeutic proteins using mammalian cell cultures. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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