Local Radiation Enhances Systemic CAR T Cell Efficacy by Augmenting Antigen Cross-Presentation and T-cell Infiltration

Autor: Kostopoulos, Nektarios, Costabile, Francesca, Krimitza, Elisavet, Beghi, Silvia, Goia, Denisa, Perales, Renzo, Thyfronitis, George, LaRiviere, Michael J., Chong, Elise A, Schuster, Stephen J., Maity, Amit, Koumenis, Constantinos, Plastaras, John P., Facciabene, Andrea
Zdroj: Blood Advances; 20240101, Issue: Preprints
Abstrakt: •Two fractions of low-dose RT enhance antitumor responses in both irradiated and non-irradiated sites when combined with CART-19 therapy.•Enhanced responses from two fractions of RT are linked to activation of the STING pathway, TAA cross-priming, and epitope spreading.
Databáze: Supplemental Index