| Autor: |
Sonowal, Angshuman, Bharali, Alakesh, Saikia, Trideep, Kushari, Susankar, Lahon, Madhuchandra, Kalita, Jun Moni, Biswas, Nikhil, Laloo, Damiki, Sahu, Bhanu P. |
| Zdroj: |
Future Journal of Pharmaceutical Sciences; December 2024, Vol. 10 Issue: 1 |
| Abstrakt: |
Background: Carbon dots (CDs) derived from Citrus aurantifoliarepresent a promising platform for advanced cancer therapy and diagnostics (theranostics). These CDs are synthesized through a sustainable and cost-effective hydrothermal method, utilizing fruit juice as a green carbon source. Despite the potential, research on the synthesis of citrus-based CDs, especially regarding their red fluorescence emission, which is crucial for enhanced tissue penetration and biomedical efficacy, remains limited. Results: In this study, CDs were successfully synthesized from C. aurantifoliafruit, yielding nanoparticles below 5 nm in size (PDI 0.231 ± 0.04). Characterization revealed favorable optical properties, including excitation-dependent fluorescent behavior with prominent red emission under higher excitation wavelengths, a quantum yield of 8.17%, and stable photoluminescence. Chemical composition analysis using XPS, FTIR, and XRD confirmed the purity and structure of the CDs. Conclusion: This research underscores C. aurantifoliaas a viable natural source for green CD synthesis. The obtained CDs with red fluorescence emission, optimized through reaction conditions and excitation wavelengths, hold promise for enhanced biological applications, particularly in the realm of lung cancer therapy. The findings advocate for further exploration and refinement of citrus-based CDs as versatile theranostic agents, capitalizing on their sustainable origins and potent biomedical properties. The combination of citrus-derived CDs with curcumin loaded into liposomal formulations represents a potent theranostic strategy for lung cancer treatment, leveraging the unique properties of CDs and their potential for targeted and effective therapy. Graphical abstract: ![]() |
| Databáze: |
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