| Autor: |
Paravicini, G., Steinmayr, M., André, E., Becker-André, M. |
| Zdroj: |
Biochemical and Biophysical Research Communications; October 1996, Vol. 227 Issue: 1 p82-87, 6p |
| Abstrakt: |
We have cloned proteins that interact with the nuclear orphan receptor RZRβ using the yeast two-hybrid system. We identified, amongst a number of other genes, the nucleoside diphosphate kinase (NDPK)-2 also known as Nm23-2, c-mycregulatory factor PuF and differentiation inhibitory factor. RZRβ specifically interacts with Nm23-2 but not with the closely related tumor metastasis suppressor candidate gene product Nm23-1. In contrast, RORα interacts with both Nm23 proteins. These findings were corroborated byin vitrointeraction assays based on GST-pulldown experiments. With n-mycwe propose a candidate gene regulated by RORα/RZRβ and Nm23, based on the finding that the respective DNA binding sites in the first intron are conserved in several mammalian species. |
| Databáze: |
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