Changes in fluconazole pharmacokinetics can impact on antifungal effectiveness in critically ill burn patients: a Pharmacokinetic-Pharmacodynamic (PK/PD) approach

Autor: Matsuno, Victor Kaneko, Campos, Edvaldo Vieira de, Silva Junior, Elson Mendes da, Silva Junior, João Manoel da, Gomez, David de Souza, Santos, Silvia Regina Cavani Jorge
Zdroj: Clinics; January-December 2024, Vol. 79 Issue: 1
Abstrakt: •Fluconazole pharmacokinetics is significantly altered in critically ill burn patients.•Half-life and total body clearance were correlated to volume of distribution decrease.•High-dose fluconazole may be necessary to guarantee coverage against Candida glabrata.
Databáze: Supplemental Index