| Autor: |
Qian, Ying, Wang, Jingming, Geng, Xudong, Jia, Bingqing, Wang, Lei, Li, Yong‐Qiang, Geng, Bijiang, Huang, Weimin |
| Zdroj: |
Advanced Healthcare Materials; September 2024, Vol. 13 Issue: 22 |
| Abstrakt: |
The exploration of sonodynamic therapy (SDT) as a possible replacement for antibiotics by creating reactive oxygen species (ROS) is suggested as a non‐drug‐resistant theranostic method. However, the low‐efficiency ROS generation and complex tumor microenvironment which can deplete ROS and promote tumor growth will cause the compromised antibacterial efficacy of SDT. Herein, through an oxygen vacancy engineering strategy, TiO2−xmicrospheres with an abundance of Ti3+are synthesized using a straightforward reductant co‐assembly approach. The narrow bandgaps and Ti3+/Ti4+‐mediated multiple‐enzyme catalytic activities of the obtained TiO2−xmicrospheres make them suitable for use as sonosensitizers and nanozymes. When graphene quantum dot (GQD) nanoantibiotics are deposited on TiO2−xmicrospheres, the resulting GQD/TiO2−xshows an increased production of ROS, which can be ascribed to the accelerated separation of electron–hole pairs, as well as the peroxidase‐like catalytic activity mediated by Ti3+, and the depletion of glutathione mediated by Ti4+. Moreover, the catalytic activities of TiO2−xmicrospheres are amplified by the heterojunctions‐accelerated carrier transfer. In addition, GQDs can inhibit Topo I, displaying strong antibacterial activity and further enhancing the antibacterial activity. Collectively, the combination of GQD/TiO2−x‐mediated SDT/NCT with nanoantibiotics can result in a synergistic effect, allowing for multimodal antibacterial treatment that effectively promotes wound healing. TiO2−xmicrospheres with an abundance of Ti3+defects are synthesized using a straightforward reductant co‐assembly approach. After depositing graphene quantum dots (GQDs) on TiO2−xmicrospheres, GQD/TiO2−xheterojunctions show an increased production of ROS. GQDs can inhibit Topo I, displaying strong antibacterial activity and further enhancing the antibacterial activity of GQD/TiO2−x‐mediated synergetic sonodynamic and nanocatalytic therapy. |
| Databáze: |
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