| Autor: |
Lin, Y., Jones, G. B., Hwang, G.-S., Kappen, L., Goldberg, I. H. |
| Zdroj: |
Organic Letters; January 2005, Vol. 7 Issue: 1 p71-74, 4p |
| Abstrakt: |
A designed molecule with capacity to bind DNA bulges (20) has been prepared from readily available starting materials. The spirocyclic template was modeled on a metabolite of neocarzinostatin chromophore (NCSi-gb) and is equipped with functionality to enable convenient bioassay. Preliminary studies confirm binding at specific bulged sequences and induction of polymerase-mediated slippage events. The target compound offers a convenient means to study affinity for unique bulged motifs and for use as a molecular biology reagent. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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