| Autor: |
Hale, J. J., Lynch, C. L., Neway, W., Mills, S. G., Hajdu, R., Keohane, C. A., Rosenbach, M. J., Milligan, J. A., Shei, G.-J., Parent, S. A., Chrebet, G., Bergstrom, J., Card, D., Ferrer, M., Hodder, P., Strulovici, B., Rosen, H., Mandala, S. |
| Zdroj: |
Journal of Medicinal Chemistry; December 2004, Vol. 47 Issue: 27 p6662-6665, 4p |
| Abstrakt: |
Moderately potent, selective S1P1 receptor agonists identified from high-throughput screening have been adapted into lipophilic tails for a class of orally bioavailable amino acid-based S1P1 agonists represented by 7. Many of the new compounds are potent S1P1 agonists that select against the S1P2, S1P3, and S1P4 (although not S1P5) receptor subtypes. Analogues 18 and 24 are highly orally bioavailable and possess excellent pharmacokinetic profiles in the rat, dog, and rhesus monkey. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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