Hypothermic oxygenated perfusion of the donor heart in heart transplantation: the short-term outcome from a randomised, controlled, open-label, multicentre clinical trial

Autor: Rega, Filip, Lebreton, Guillaume, Para, Marylou, Michel, Sebastian, Schramm, René, Begot, Emmanuelle, Vandendriessche, Katrien, Kamla, Christine, Gerosa, Gino, Berman, Marius, Boeken, Udo, Clark, Steven, Ranasinghe, Aaron, Ius, Fabio, Forteza, Alberto, Pivodic, Aldina, Hennig, Felix, Guenther, Sabina, Zuckermann, Andreas, Knosalla, Christoph, Dellgren, Göran, Wallinder, Andreas, Van Cleemput, Johan, Degezelle, Karlien, Wert, Leonhard, Yeter, Ruhi, Lichtenberg, Artur, Aubin, Hug, Görler, Adelheid, Freyt, Susanne, McDiarmid, Adam, Jungschleger, Jerome, Mukadam, Majid, Turner, Paul, Mullen, Rebecca, Hernández, Francisco, Ospina, Victor, Jonsson, Kristjan, Ternström, Lisa, Al Kalbani, Hamed, Djavidi, Nima, Fabozzo, Assunta, Pradegan, Nicola, Aliabadi-Zuckermann, Arezu, Osorio, Emilio
Zdroj: The Lancet; August 2024, Vol. 404 Issue: 10453 p670-682, 13p
Abstrakt: Static cold storage (SCS) remains the gold standard for preserving donor hearts before transplantation but is associated with ischaemia, anaerobic metabolism, and organ injuries, leading to patient morbidity and mortality. We aimed to evaluate whether continuous, hypothermic oxygenated machine perfusion (HOPE) of the donor heart is safe and superior compared with SCS.
Databáze: Supplemental Index