CpG oligonucleotides induce acute murine thrombocytopenia dependent on toll-like receptor 9 and spleen tyrosine kinase pathways

Autor: Johansson, Karl, Maouia, Amal, Rebetz, Johan, Marcoux, Geneviève, Shannon, Oonagh, Italiano, Joseph E., Narayanan, Padma, Henry, Scott, Shen, Lijiang, Semple, John W.
Zdroj: Journal of Thrombosis and Haemostasis; November 2024, Vol. 22 Issue: 11 p3266-3276, 11p
Abstrakt: CpG oligonucleotides (ODNs) are synthetic single-stranded DNA sequences that act as immunostimulants. They have been increasingly used to treat several cancers; however, thrombocytopenia is a potential recognized side effect of some sequences.
Databáze: Supplemental Index