| Autor: |
Sizek, Herbert, Deritei, Dávid, Fleig, Katherine, Harris, Marlayna, Regan, Peter L., Glass, Kimberly, Regan, Erzsébet Ravasz |
| Zdroj: |
Translational Oncology; November 2024, Vol. 49 Issue: 1 |
| Abstrakt: |
•Boolean regulatory network model reproduces mitochondrial dynamicsduring cell cycle progression, apoptosis, and glucose starvation.•Model offers a mechanistic explanation for the positive feedback loop that locks in Mitochondrial Dysfunction-Associated Senescence(MiDAS), involving autophagy-resistant, hyperfused, dysfunctional mitochondria.•Model reproduces ROS-mediated mitochondrial dysfunctionand suggests that MiDAS is part of the early phase of damage-induced senescence.•Model predictsthat cancer-driving mutations that bypass the G1/S checkpoint generally increase the incidence of MiDAS, except for p53 loss. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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