| Abstrakt: |
Bioactive glasses (BG) are one of the most intriguing and well-known biomaterials due to their biocompatibility and bioactivity characteristics. It has several uses, such as bone tissue engineering and the regeneration of missing oral and maxillofacial tissues. Because of this, researchers are now paying attention to the possibility of regenerating damaged skeletal muscle. Our goal was to thoroughly examine the research on BG’s potential and application typically linked to bone for the best possible muscle regeneration. This systematic review complies with Preferred Reporting Items for Systematic and Meta-Analysis (PRISMA) criteria. An automated search in leading traditional scientific databases was conducted without any language or publication date restrictions across Scopus, PubMed/Medline, Web of Science, and Clinicaltrials.gov platforms which produced predominantly the majority of the article findings. During this process, the authors checked a few gray literature databases (not traditional/academic), which resulted in a few article additions. Utilizing the Joanna Briggs Institute (JBI) critical evaluation checklist for quasi-experimental research, the risk of bias in the articles of eligible studies was evaluated in relation to the inclusion/exclusion criteria. So, a discourse was conducted to settle any differences between the two reviewers regarding the eligibility and quality of the study. With reference to Population, Intervention, Comparison, and Outcome (PICO) criteria, the authors developed the specific question, “How can BGs, which are normally associated with bone healing, be tailored for the greatest potential muscle regeneration?” A total of 101 publications were obtained using citation search, gray literature, and electronic databases. After removing duplicates, 80 titles and abstracts were obtained from the first screening phase. Six studies that used various classes of BG as a powder or scaffold for skeletal muscle cell regeneration were examined and tallied following the records’ evaluation according to PICO criteria. There was one moderate risk of bias and five low risk of bias in these studies. The findings of these investigations show that BGs are compatible with muscle cells, promote C2C12 gene proliferation, and facilitate the expression and differentiation of skeletal muscle genes in both in vitro and in vivo settings. According to the results of the current systematic review, bioactive glass is a valuable biomaterial for skeletal muscle regeneration and may represent a new class of biomaterials with enhanced regenerative potential. Moreover, further controlled clinical studies are warranted. |
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