| Autor: |
Liu, Ying, Qing, Zhao, Qin, RuoMeng, Chen, HaiFeng, Ye, Qing, Li, MengChun, Luo, CaiMei, Liu, Renyuan, Xu, Yun, Zhao, Hui, Zhang, Bing |
| Zdroj: |
Chinese Journal of Academic Radiology; September 2024, Vol. 7 Issue: 3 p264-276, 13p |
| Abstrakt: |
Background: Mild cognitive impairment (MCI), regarded as the prodromal stage before the clinical phase of Alzheimer’s disease (AD), has been considered for early differential diagnosis. Patients with amnestic mild cognitive impairment (aMCI), an important subtype of MCI, are more likely to progress to clinical Alzheimer disease (AD). Objective: To examine the structural and functional connectome in both kinds of MCI and found differences in structural connectivity (SC)-functional connectivity (FC) coupling. Methods: Fifty-nine individuals with aMCI, non-amnestic mild cognitive impairment (naMCI) and healthy controls (NC) underwent resting-state functional magnetic resonance imaging (rs-fMRI) and diffusion tensor imaging (DTI). Brains were parcellated into functional modules according to the FC networks of NC, and individual FC and SC within modules as well as average FC, average SC and average SC-FC correlation values in each module among groups were analyzed, while logistic regression was used to find predictive factors. Results: After controlling for age, sex, and education, the FC values in the temporal-occipital module and the SC-FC correlation values in the temporal-occipital and the default mode module appeared associated with the prediction of aMCI. Conclusion: These modular connectivity values can be used for further study of MCI subtypes. |
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