| Autor: |
Khader, Wesam, Kayali, Mohamed K., Eddin, Tawfik M. Taj, Alameri, Abdul Hadi S. S. S., Aziz, Mughair Abdul, Kizhakkayil, Jaleel, Senthilkumar, Annadurai, Al Dhaheri, Ayesha S., Jaleel, Abdul |
| Zdroj: |
Advances in Traditional Medicine; 20240101, Issue: Preprints p1-12, 12p |
| Abstrakt: |
Indigenous plants from arid regions are known for their diverse applications in traditional medicine. These plants are particularly promising as potential anticancer agents due to their ability to produce a wide range of secondary metabolites. The present study addressed the problem of identifying and evaluating the anticancer properties of crude extracts from indigenous arid-region plants, Calligonum comosumL.’Her. and Calligonum crinitumBoiss., to determine their efficacy against human breast (MCF-7) and human colon adenocarcinoma (Caco-2) cell lines. Through various solvent-treated leaf extracts, including hexane, methanol, acetone, and chloroform, we aimed to determine the antiproliferative activities and identify extracts with promising efficacy in inhibiting cancer cell viability. The morphological changes and anticancer effects induced by these solvent-treated C. comosumand C. crinitumleaf extracts were investigated. Our results indicated that the use of acetone isolated leaf extracts on the MCF-7 cells displayed apoptotic morphological changes. Similarly, the MTT cytotoxicity assay revealed that the acetone-treated extracts of C. comosumand C. crinitumshowed a significant inhibitory effect on MCF-7 cell lines, with IC50values of 24.62 μg/ml and 23.41 μg/ml, respectively. Conversely, the other solvents resulted in higher IC50values for inhibiting the MCF-7 cell proliferation. While for the Caco-2 cell lines, we observed remarkable antiproliferation activity, with IC50values of 37.76 µg/ml and 74.88 µg/ml for the C. comosumand C. crinitumchloroform-isolated extracts, respectively, in comparison to the hexane, methanol, and acetone-isolated extracts. These findings suggest that the extracts of C. comosumand C. crinitumpossess significant potential for inhibiting the viability of MCF-7 and Caco-2 cancer cell lines, indicating their possible use as anticancer agents. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
|
Full text from SpringerLink