| Autor: |
Fesneau, Olivier, Thevin, Valentin, Pinet, Valérie, Goldsmith, Chloe, Vieille, Baptiste, M’Homa Soudja, Saïdi, Lattanzio, Rossano, Hahne, Michael, Dardalhon, Valérie, Hernandez-Vargas, Hector, Benech, Nicolas, Marie, Julien C. |
| Zdroj: |
Nature Immunology; 20240101, Issue: Preprints p1-13, 13p |
| Abstrakt: |
Approximately 25% of cancers are preceded by chronic inflammation that occurs at the site of tumor development. However, whether this multifactorial oncogenic process, which commonly occurs in the intestines, can be initiated by a specific immune cell population is unclear. Here, we show that an intestinal T cell subset, derived from interleukin-17 (IL-17)-producing helper T (TH17) cells, induces the spontaneous transformation of the intestinal epithelium. This subset produces inflammatory cytokines, and its tumorigenic potential is not dependent on IL-17 production but on the transcription factors KLF6 and T-BET and interferon-γ. The development of this cell type is inhibited by transforming growth factor-β1 (TGFβ1) produced by intestinal epithelial cells. TGFβ signaling acts on the pretumorigenic TH17 cell subset, preventing its progression to the tumorigenic stage by inhibiting KLF6-dependent T-BET expression. This study therefore identifies an intestinal T cell subset initiating cancer. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
|
Full text from SpringerLink