Interleukin-1 blockade in patients with Wiskott-Aldrich syndrome: a retrospective multinational case series

Autor: Naviglio, Samuele, Cicalese, Maria Pia, Rivers, Elizabeth, Ferrua, Francesca, Bonfim, Carmem, Cenciarelli, Sabina, Cheong, Kai-Ning, Faraci, Maura, Giardino, Stefano, Ghosh, Sujal, Lee, Pamela P., Lyra, Paula Teixeira, Meisel, Roland, Sofia, Valentina, Tessitore, Antimo, Tommasini, Alberto, Valencic, Erica, Vallée, Tanja Christine, Volpi, Stefano, Worth, Austen J., Rabusin, Marco, Albert, Michael H., Thrasher, Adrian J., Aiuti, Alessandro
Zdroj: Blood; October 2024, Vol. 144 Issue: 16 p1699-1704, 6p
Abstrakt: •Patients with Wiskott-Aldrich syndrome can develop inflammatory manifestations poorly controlled by corticosteroid therapy.•Treatment with anti–IL-1 agents resulted in dramatic responses, suggesting an autoinflammatory pathogenesis.
Databáze: Supplemental Index