| Autor: |
Guo, Haixia, Yu, Jinguo, He, Tiangeng, Chen, Song, Sun, Zhuoyu, Zhang, Jingkai, Sun, Zhiyong, Yang, Wenhui, Yao, Baoqun, Yang, Xueli, Liu, Yuanyuan, Zhang, Mingxue, Meng, Yu, Yang, Likun, Yan, Hua |
| Zdroj: |
British Journal of Ophthalmology; 2024, Vol. 108 Issue: 8 p1161-1167, 7p |
| Abstrakt: |
AimsTo evaluate the efficacy and safety of intravitreal triamcinolone acetonide (TA) injection at the end of emergency surgery for open globe injury (OGI) to suppress traumatic proliferative vitreoretinopathy (TPVR).MethodsA single-centre, participant-masked, prospective, randomised controlled clinical trial. A total of 68 globe rupture patients with zone III were randomised to the control group (n=34) or the TA group (n=34) in 1:1 allocation ratio. Patients were treated with 0.1 mL TA in the TA group and 0.1 mL balanced salt solution in the control group at the end of emergency surgery. The primary outcome was the assessment of TPVR during vitrectomy 10±3 days later. Secondary outcomes included visual acuity (VA), retinal attachment rate, macular attachment rate, proliferative vitreoretinopathy (PVR) recurrent rate, side effects 6 months after vitrectomy.ResultsDuring vitrectomy, the TPVR grade of the control group was significantly more severe than the TA group (p=0.028). The TPVR score was significantly better in the TA group (9.30±0.82) than in the control group (6.44±1.06) (p=0.036). The final VA improved in 23 eyes (92%) in the TA group and in 14 eyes (63.64%) in the control group (p=0.008). The retinal attachment rates were 88% and 63.64% in the TA and control group, respectively (p=0.049). The two groups showed no significant difference in macular repositioning and PVR recurrent rate (p=0.215, 0.191). Temporary intraocular pressure elevation occurred in one eye in the TA group after emergency surgery.ConclusionsEarly intravitreal TA injection for OGI effectively reduces TPVR, increases surgical success and improves visual prognosis. |
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