Cumulative donor-specific antibody threshold predicts platelet transfusion response in HLA-alloimmunized patients

Autor: Boothby, Aaron B., Tanner, Matthew K., Alswied, Abdullah, Youngs, Danny, Bribiesca Rodriguez, Josefine, Bikkani, Thejaswi, Cha, Nuri, Gernsheimer, Terry, Gimferrer, Idoia, Hess, John R., Sokol-Hessner, Lauge, Marivada, Snigdha, Nash, Michael G., Flegel, Willy A., Vassallo, Ralph R., Stroncek, David F., Tsang, Hamilton C., Panch, Sandhya R.
Zdroj: Blood Advances; September 2024, Vol. 8 Issue: 17 p4689-4699, 11p
Abstrakt: •In severe HLA-alloimmune platelet transfusion refractoriness, DSA-MFI sums >10 000 and major-ABO mismatch actionably predict poor 2-hour CCI.•Computer-aided histocompatibility ranking to lower DSA-MFI sums may streamline donor selection and improve CCIs.
Databáze: Supplemental Index