| Autor: |
Storr, Tim, Obata, Makoto, Fisher, Cara L., Bayly, Simon R., Green, David E., Brudziñska, Izabela, Mikata, Yuji, Patrick, Brian O., Adam, Michael J., Yano, Shigenobu, Orvig, Chris |
| Zdroj: |
Chemistry - A European Journal; January 2005, Vol. 11 Issue: 1 p195-203, 9p |
| Abstrakt: |
Seven discrete sugar‐pendant diamines were complexed to the {M(CO)3}+(99mTc/Re) core: 1,3‐diamino‐2‐propyl β‐D‐glucopyranoside (L1), 1,3‐diamino‐2‐propyl β‐D‐xylopyranoside (L2), 1,3‐diamino‐2‐propyl α‐D‐mannopyranoside (L3), 1,3‐diamino‐2‐propyl α‐D‐galactopyranoside (L4), 1,3‐diamino‐2‐propyl β‐D‐galactopyranoside (L5), 1,3‐diamino‐2‐propyl β‐(α‐D‐glucopyranosyl‐(1,4)‐D‐glucopyranoside) (L6), and bis(aminomethyl)bis[(β‐D‐glucopyranosyloxy)methyl]methane (L7). The Re complexes [Re(L1–L7)(Br)(CO)3] were characterized by 1H and 13C 1D/2D NMR spectroscopy which confirmed the pendant nature of the carbohydrate moieties in solution. Additional characterization was provided by IR spectroscopy, elemental analysis, and mass spectrometry. Two analogues, [Re(L2)(CO)3Br] and [Re(L3)(CO)3Br], were characterized in the solid state by X‐ray crystallography and represent the first reported structures of Re organometallic carbohydrate compounds. Conductivity measurements in H2O established that the complexes exist as [Re(L1–L7)(H2O)(CO)3]Br in aqueous conditions. Radiolabelling of L1–L7with [99mTc(H2O)3(CO)3]+afforded in high yield compounds of identical character to the Re analogues. The radiolabelled compounds were determined to exhibit high in vitro stability towards ligand exchange in the presence of an excess of either cysteine or histidine over a 24 h period. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
|
Plný text