| Autor: |
Strange, Richard C., El‐Genidy, Noha, Ramachandran, Sudarshan, Lovatt, Tracy J., Fryer, Anthony A., Smith, Andrew G., Lear, John T., Ichii‐Jones, Fumiyo, Jones, Peter W., Hoban, Paul R. |
| Zdroj: |
Environmental and Molecular Mutagenesis; 2004, Vol. 44 Issue: 5 p469-476, 8p |
| Abstrakt: |
After first presentation with a basal cell carcinoma (BCC), patients demonstrate interindividual diversity in the rate of development of further BCCs (number/year of follow‐up). The mechanism for this variation is unknown. In this study, we evaluated whether PTCHvariants mediate this phenomenon. We used negative binomial regression analysis to identify associations between BCC numbers/year and host characteristics, parameters of exposure to ultraviolet radiation (UVR), and PTCHexon 121686C/T, intron 152560+9G/C, and exon 233944C/T genotypes and haplotypes in 279 BCC cases who presented with an initial tumor on the head/neck. PTCHgenotypes were not significantly associated with BCCs/year, although cases with two copies of the C1686‐C3944haplotype developed significantly fewer BCCs/year than those without this haplotype (rate ratio = 0.44; 95% CI = 0.27–0.71). Cases with one copy of T1686‐T3944developed more BCCs/year (rate ratio = 2.46; 95% CI = 1.27–3.97) than those without the haplotype. We found no significant associations between BCCs/year and the other PTCHhaplotypes studied. We reexamined the association of C1686‐C3944with BCCs/year in a model that included UVR exposure parameters (sunburning in childhood, sunbathing score, intermittency of exposure between 40 and 60 years of age, exposure in hours/year) and skin type, gender, and age at first presentation. The association between C1686‐C3944and BCCs/year remained significant (rate ratio = 0.44; 95% CI = 0.26–0.73 for two copies of the haplotype). The data show that allelic variation in PTCHcontributes to the rate of development of BCC. Environ. Mol. Mutagen., 2004. © 2004 Wiley‐Liss, Inc. |
| Databáze: |
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