Biological Activity of Quaternary Ammonium Salts Containing 1,3-Dioxolane or gem-Dichlorocyclopropane Fragment

Autor:	Raskil’dina, G. Z., Borisova, Yu. G., Vereshchagin, A. N., Detusheva, E. V., Sultanova, R. M., Zlotskii, S. S.
Zdroj:	Reviews and Advances in Chemistry; March 2024, Vol. 14 Issue: 1 p16-21, 6p
Abstrakt:	Abstract: Quaternary ammonium salts (QASs) containing gem-dichlorocyclopropane and 1,3-dioxacycloalkane fragments were prepared in 40–90% yields based on pyridine, hexamethylenetetramine, and tertiary amines. The structures of the obtained salts were identified by 1H and 13C NMR spectroscopy. The antibacterial activity of QAS against a bacterial strain (Escherichia coli, Klebsiella pneumoniae, S. aureus, and Acinobacter Baumanii) were assessed.Among the salts tudied, leader compounds were identified that exhibited high antibacterial activity.
Databáze:	Supplemental Index
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