Synthesis and Characterization of Related Substances of Lopinavir

Autor: Kishore, Merusomayajula V., Rao, T. Siva, Garaga, Srinivas, Kommula, Ramasrinivas, Sathyendranath, Chakkirala Venkata
Zdroj: Chemistry Africa; 20240101, Issue: Preprints p1-6, 6p
Abstrakt: Lopinaviris chemically known as (2 S,3 S,5 S)-2-(2,6-dimethylphenoxyacetyl) amino-3-hydroxy-5-[2-(1-tetrahydropyrimid-2-only)-3-methylbutanoyl]amino-1,6-diphenyl hexane. This paper describes the synthesis and characterization of lopinavir USP related substance D (sulfolopinavir), USP related substance E (Lopinavirphenoxyacetamide) and USP related substance H (Lopinaviroxazine impurity). All three related substances (impurities) of Lopinavir namelysulfolopinavir, Lopinavirphenoxyacetamide and Lopinaviroxazine impurity has been synthesized with good yield and successfully characterized with different separation and spectroscopic techniques.The present work describes the formation, synthesis and characterization of the impurities of Lopinavir. This work will help pharmaceutical professionals to produce respective impurities for regular usage in quality control laboratory for various peak identification purposes.
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