Non-Enzymatic Electrochemical Detection of Urine Creatinine Using Cobalt-Gold Bimetallic Nanoparticles

Autor: R., Meera, P. K., Neena, Pradeep, Aarathi, G. Nair, Bipin, Punathil Vasu, Suneesh, Satheesh Babu, T. G.
Zdroj: Journal of the Electrochemical Society; June 2024, Vol. 171 Issue: 6 p067504-067504, 1p
Abstrakt: This work presents the development of a non-enzymatic electrochemical sensor for creatinine in a neutral medium using a cobalt-gold bimetallic nanoparticles modified platinum electrode. The voltammetric detection of creatinine in a neutral phosphate buffer was based on the formation of a soluble cobalt-creatinine complex. The sensor exhibited good selectivity and a detection limit (S/N = 3) of 2.25 mM with two linear ranges from 6.4 to 83.2 mM. The sensitivity of the sensor was 0.621 and 1.135 μA mM−1cm−2at lower (6.4–51.2 mM) and higher (51.2–83.2 mM) detection ranges, respectively. The sensor performance was validated using urine samples and creatinine spiked urine samples.
Databáze: Supplemental Index