| Autor: |
Huang, X., Palani, A., Xiao, D., Aslanian, R., Shih, N.-Y. |
| Zdroj: |
Organic Letters; December 2004, Vol. 6 Issue: 25 p4795-4798, 4p |
| Abstrakt: |
A new efficient two-step synthesis of 2,4-dihydro-3H-1,2,4-triazolin-3-ones (triazolinones) from readily available amines is reported. Our novel conditions using hexamethyl disilazane, bromotrimethylsilane, and a catalytic amount of ammonium sulfate smoothly cyclize 1-formyl and 1-acetyl semicarbazides to the target triazolinones. This transformation features simultaneous manipulation of N- and O-nucleophilicity as well as differentiation of the nucleophilicity of a urea and an acyl carbonyl. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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