| Autor: |
Peelen, T. J., Chi, Y., English, E. P., Gellman, S. H. |
| Zdroj: |
Organic Letters; November 2004, Vol. 6 Issue: 24 p4411-4414, 4p |
| Abstrakt: |
An enantioselective synthetic route is reported for trans-2-aminocyclopentanecarboxylic acids (ACPC) bearing geminal side chain pairs at the 4-position. β-Peptides containing the 4,4-disubstituted ACPC residues adopt the 12-helical conformation, as demonstrated by 2D NMR analysis in aqueous solution. These 4,4-disubstituted ACPC residues display functional groups, including acidic and hydrogen bond donating groups, in a geometrically defined fashion, which should be useful for the design of β-peptides for specific applications. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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