| Autor: |
Oliveira, J. H. H. L. de, Grube, A., Kock, M., Berlinck, R. G. S., Macedo, M. L., Ferreira, A. G., Hajdu, E. |
| Zdroj: |
Journal of Natural Products; October 2004, Vol. 67 Issue: 10 p1685-1689, 5p |
| Abstrakt: |
The chemical investigation of the cytotoxic and antituberculosis active MeOH crude extract of the marine sponge Pachychalina sp. led to the isolation of six new nitrogenous metabolites, including ingenamine G (1), as well as a mixture of new cyclostellettamines G, H, I, K, and L (10−14) with the known cyclostellettamines A−F (4−9). Structural assignments of compound 1 were based on the analysis of MS and NMR data, while the structures of compounds 10−14 could be established by HPLC-MS/MS analysis. Ingenamine G displayed cytotoxic activity against HCT-8 (colon), B16 (leukemia), and MCF-7 (breast) cancer cell lines, antibacterial activity against Staphylococcus aureus (ATCC 25923), Escherichia coli (ATCC 25922), and four oxacilin-resistant S. aureus strains, and antimycobacterial activity against Mycobacterium tuberculosis H37Rv. |
| Databáze: |
Supplemental Index |
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