Optimizing cancer patient care with a robust assay for 5-fluorouracil quantification and in-vitro stability in human blood for therapeutic drug monitoring

Autor: Gurjar, Murari, Priyan, K. Ambedkar, Asia, Priyanka, Kumar, Uday, Shukla, Kajal, Mishra, Bal Krishna, Kapoor, Akhil, Gavel, Pratibha
Zdroj: Practical Laboratory Medicine; May 2024, Vol. 40 Issue: 1
Abstrakt: The plasma concentration of 5-Fluorouracil (5-FU) is affected by numerous factors, thereby limiting its efficacy. The current therapeutic regimen's doses based on body surface area (BSA) are linked to increased toxicity and sometimes inadequate drug exposure.
Databáze: Supplemental Index