Cloning and Characterization of a Human and Murine T-Cell Orphan G-Protein-Coupled Receptor Similar to the Growth Hormone Secretagogue and Neurotensin Receptors

Autor: Tan, Carina P., McKee, Karen Kulju, Liu, Qingyun, Palyha, Oksana C., Feighner, Scott D., Hreniuk, Donna L., Smith, Roy G., Howard, Andrew D.
Zdroj: Genomics; September 1998, Vol. 52 Issue: 2 p223-229, 7p
Abstrakt: Growth hormone secretagogues (GHS) are a group of synthetic peptide and nonpeptide molecules that potently stimulate the release of GH from the anterior pituitary gland through the activation of a novel G-protein-coupled receptor (GPC-R), the GHS-R. In our search for GHS-R family members, we recently described the cloning of two related GPC-Rs, GPR38 and 39. In the present report, we detail the isolation of a new GPC-R (FM-3) from human and mouse with moderate sequence identity to both the GHS-R and neurotensin-R. FM-3 is expressed in a diverse set of tissues.
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