| Autor: |
Wang, Yakun, Wang, Yingying, Guo, Wenwen, Zhang, Yizhe, Du, Xiaoyu, Song, Yan, Wang, Wenhui, Liu, Zhiang, Duan, Yingchao, Zhang, Tao |
| Zdroj: |
The Journal of Organic Chemistry; June 2024, Vol. 89 Issue: 11 p8011-8022, 12p |
| Abstrakt: |
We successfully developed an enantioselective trifluoromethylthiolation of structurally diverse carbonyl compounds. Trichloroisocyanuric acid and AgSCF3were employed to generate active electrophilic trifluoromethylthio species in situ for asymmetric C-SCF3bond formation. A broad variety of chiral SCF3-carbon nucleophiles (pyrazolones, β-keto esters, and β-keto amides) were obtained in excellent yields with high enantioselectivities (up to 92% ee) by Cinchona alkaloid derived squaramide catalysts. The reaction exhibits high efficiency, good enantioselectivity, and high functional group tolerance, which provided a novel and efficient way for asymmetric synthesis of trifluoromethylthiolated carbonyl compounds. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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