| Autor: |
Antunez, Maria Inés, Feinstein, Ricardo E., Cardoni, Rita L., Grönvik, Kjell-Olov |
| Zdroj: |
Experimental Parasitology; September 1997, Vol. 87 Issue: 1 p58-64, 7p |
| Abstrakt: |
The changes in the T cell subsets of the Peyer's patches and the thymus were analyzed in BALB/c mice infected withTrypanosoma cruzi,Tulahuén strain. During the acute stage of the infection both lymphoid organs drastically reduced their cellularity. This was mainly due to the decrease in the immature CD4+CD8+T cell population in the thymus and in both T and B cells in the Peyer's patches. In the acute infection, few Peyer's patches were found and the histological studies revealed a depletion of the thymic-dependent areas, paralleling the decreased number of cells expressing CD4 and αβ T cell receptor. After 14 weeks, in the late stage of the infection, the cellularity and the levels of the T cell subsets studied returned to values similar to those of noninfected mice. |
| Databáze: |
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